Patogeenien annosvasteet

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Versio hetkellä 18. elokuuta 2011 kello 09.23 – tehnyt Päivi Meriläinen (keskustelu | muokkaukset) (Viitteet lisätty)
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Rajaus

Juomaveden patogeenien annosvasteet.

Määritelmä

Data

Pathogen Referenssi
Kampylobakteeri Campylobacter (Teunis et al. 2005) Exact Beta-Poisson model Low Dose Approximation:Dose Response relationship for Campylobacter from model fit results presented by Teunis et al. (2005) Epidemiol. Infec. 133, 583-592. The exact hypergeometric beta-poisson model was fitted to outbreak data. alpha = 0.024, beta = 0.011.
  • Here the hypergeometric function is approximated at low doses as the exponential function with r= alpha/alpha+beta

Campylobacter (Teunis et al. 2005) Exact Beta-Poisson model: Dose Response relationship for Campylobacter from model fit results presented by Teunis et al. (2005) Epidemiol. Infec. 133, 583-592.

  • The exact hypergeometric beta-poisson model was fitted to outbreak data. alpha = 0.024, beta = 0.011.
E.coli O157:H7 Teunis et al., 1996 RIVM report No. 284550002 "The dose-response relation in human volunteers for gastro-intestinal pathogens"?
Rotavirus eunis et al., 1996 RIVM report No. 284550002 where the beta-poisson approximation was fitted to data from Ward et al. 1986 Journal of Infectious Diseases 154, 871-880
Norovirus Teunis et al. 2008 Norwalk Virus: How Infectious is It? Journal of Medical Virology 80:1468-1476.
  • Parameter values for combined dataset - Table III
Cryptosporidium Teunis et al., 2002 Risk Analysis 22(1) 175-183
Giardia Teunis et al., 1996 RIVM report No. 284550002 " The dose-response relation in human volunteers for gastro-intestinal pathogens"



Yksikkö

Kaava

Tulokset

Patogeenien annosvasteet(-)
ObsPathogenFunction typeFunctionParam1Param2
1KampylobakteeriBeta Poisson approximation1-(1+Dose/Param2)^-Param10.0240.011
2E.coli O157:H7Alternative exponential1-(1+(Dose/Param1))^(Param2)9.16-0.157
3RotavirusExact beta Poisson1-exp(-(Param1/(Param1+Param2))*Dose)0.1670.191
4NorovirusExact beta Poisson1-exp(-(Param1/(Param1+Param2))*Dose)0.040.055
5CryptosporidiumExact beta Poisson1-exp(-(Param1/(Param1+Param2))*Dose)0.1150.176
6GiardiaExponential1-exp(-Param1*Dose)0.01990

Katso myös

http://wiki.camra.msu.edu/index.php?title=Dose_response_assessment

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